On November 2, 2025, an intriguing NFL matchup is set to take place at Acrisure Stadium in Pittsburgh, as the Indianapolis Colts go head-to-head with the Pittsburgh Steelers starting at 1:00 PM. The Colts, currently first in their division and fourth in their conference, exhibit a record of 3-1, boasting a winning percentage of 0.75. They have impressively scored 123 points while allowing 83, giving them a positive net point difference of 40. In contrast, the Steelers also hold a record of 3-1, ranked first in their division and second in the conference, but with a narrower net point difference of -2 after scoring 96 points and conceding 98. Previously, the Colts secured a win against Miami with a score of 16-10, racking up 155 rushing yards and 129 passing yards. Conversely, the Steelers claimed a commanding victory over the New York Jets with a score of 37-15, demonstrating strong offensive capabilities with 149 rushing yards and 260 passing yards. Key players in the upcoming game include Anthony Richardson for the Colts, who had 129 passing yards in his last game, and Russell Wilson for the Steelers, who threw for 264 yards and two touchdowns. The spotlight will indeed be on the quarterbacks, with both demonstrating potential to heavily influence the game’s outcome. The odds for this match reveal the Steelers as favorites with a point spread of -3.50 and moneyline at -181, while the Colts are set at a point spread of +3.50 and moneyline of +151. The over/under has been placed at 44.70. This betting scenario suggests a tight contest, leaning slightly towards a Steelers’ advantage, yet acknowledging the strong competition posed by the Colts. Football fans and bettors alike might anticipate a closely contested game, making it a critical focal point for both strategy and entertainment.